Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: a potential mechanistic role for placental peroxisome …

JT Szilagyi, V Avula, RC Fry - Current environmental health reports, 2020 - Springer
Abstract Purpose of Review This review summarizes studies highlighting perfluoroalkyl
substances (PFAS) and their effects on the placenta, pregnancy outcomes, and child health …

Placental function in maternal obesity

AC Kelly, TL Powell, T Jansson - Clinical Science, 2020 - portlandpress.com
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

[HTML][HTML] New advances in tissue metabolomics: a review

M Saoi, P Britz-McKibbin - Metabolites, 2021 - mdpi.com
Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical
medicine while also providing better understanding of the underlying mechanisms of chronic …

Maternal diet disrupts the placenta–brain axis in a sex-specific manner

AM Ceasrine, BA Devlin, JL Bolton, LA Green… - Nature …, 2022 - nature.com
High maternal weight is associated with detrimental outcomes in offspring, including
increased susceptibility to neurological disorders such as anxiety, depression and …

[HTML][HTML] Impact of maternal obesity on the metabolism and bioavailability of polyunsaturated fatty acids during pregnancy and breastfeeding

D Álvarez, Y Muñoz, M Ortiz, M Maliqueo… - Nutrients, 2020 - mdpi.com
Prenatal and postnatal development are closely related to healthy maternal conditions that
allow for the provision of all nutritional requirements to the offspring. In this regard, an …

Effect of maternal obesity on placental lipid metabolism

V Calabuig-Navarro, M Haghiac, J Minium… - …, 2017 - academic.oup.com
Obese women, on average, give birth to babies with high fat mass. Placental lipid
metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is …

[HTML][HTML] Maternal obesity: new placental paradigms unfolded

C Brombach, W Tong, DA Giussani - Trends in molecular medicine, 2022 - cell.com
The prevalence of maternal obesity is increasing at an alarming rate, and is providing a
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …

[HTML][HTML] Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity

DS Fernandez-Twinn, G Gascoin, B Musial, S Carr… - Scientific reports, 2017 - nature.com
The prevalence of obesity during pregnancy continues to increase at alarming rates. This is
concerning as in addition to immediate impacts on maternal wellbeing, obesity during …

The human placenta in diabetes and obesity: friend or foe? The 2017 Norbert Freinkel Award Lecture

G Desoye - Diabetes care, 2018 - Am Diabetes Assoc
The placenta plays a key role in sustaining fetal growth and development. Due to its position
between mother and fetus, it is exposed to changes in the intrauterine environment in both …

[HTML][HTML] Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia

A Hufnagel, L Dearden… - Journal of …, 2022 - joe.bioscientifica.com
Obesity and gestational diabetes during pregnancy have multiple short-and long-term
consequences for both mother and child. One common feature of pregnancies complicated …