Abstract The role of Natural Killer cells in host defense against infections as well as in
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …

The development of immunotherapeutic monoclonal antibodies targeting checkpoint
inhibitory receptors, such as programmed cell death 1 (PD-1), or their ligands, such as PD …

Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host
defense against pathogens. One subset of human NK cells (CD56bright) constitutively …

In this report, we establish a regulatory role of natural killer (NK) cells in experimental
autoimmune encephalomyelitis (EAE), a prototype T helper cell type 1 (Th1)-mediated …

Natural killer (NK) cells may modulate the development of adaptive immune responses, but
until now there has been little evidence to support this hypothesis. We investigated the …

We studied the role of NK cells in regulating human CD8+ T cell effector function against
mononuclear phagocytes infected with the intracellular pathogen Mycobacterium …

Dormant tumor cells resistant to ablative cancer therapy represent a significant clinical
obstacle due to later relapse. Experimentally, the murine B cell lymphoma (BCL 1) is used …

NK cells possess both effector and regulatory activities that may be important during the
antitumor immune response. In fact, the generation of antitumor immunity by the …

Abstract Background: Advanced (stage 4) cases of neuroblastoma, a childhood cancer of
the nervous system, are associated with high relapse rates, even after intensive …