Contaminants: a dark side of food supplements?
Food supplements (FS) are often consumed as one of the strategies to fight ageing-
associated pathologies, especially in the case of oxidative stress-related diseases. Despite …
associated pathologies, especially in the case of oxidative stress-related diseases. Despite …
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics
F Henkler, J Brinkmann, A Luch - Cancers, 2010 - mdpi.com
In addition to a wide range of adverse effects on human health, toxic metals such as
cadmium, arsenic and nickel can also promote carcinogenesis. The toxicological properties …
cadmium, arsenic and nickel can also promote carcinogenesis. The toxicological properties …
[HTML][HTML] Increasing scientific confidence in adverse outcome pathways: application of tailored Bradford-Hill considerations for evaluating weight of evidence
Systematic consideration of scientific support is a critical element in developing and,
ultimately, using adverse outcome pathways (AOPs) for various regulatory applications …
ultimately, using adverse outcome pathways (AOPs) for various regulatory applications …
External influences on the immune system via activation of the aryl hydrocarbon receptor
The aryl hydrocarbon receptor (AhR), subject of intensive research over three decades by
the pharmacology/toxicology field has recently made its entry into mainstream immunology …
the pharmacology/toxicology field has recently made its entry into mainstream immunology …
The role of the aryl hydrocarbon receptor in the female reproductive system
I Hernández-Ochoa, BN Karman, JA Flaws - Biochemical pharmacology, 2009 - Elsevier
In recent years, many studies have emphasized how changes in aryl hydrocarbon receptor
(AHR)-mediated gene expression result in biological effects, raising interest in this receptor …
(AHR)-mediated gene expression result in biological effects, raising interest in this receptor …
A review of the functional roles of the zebrafish aryl hydrocarbon receptors
Over the last 2 decades, the zebrafish (Danio rerio) has emerged as a stellar model for
unraveling molecular signaling events mediated by the aryl hydrocarbon receptor (AHR), an …
unraveling molecular signaling events mediated by the aryl hydrocarbon receptor (AHR), an …
Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences
Particulate matter (PM) containing environmentally persistent free radicals (EPFRs) results
from the incomplete combustion of organic wastes which chemisorb to transition metals. This …
from the incomplete combustion of organic wastes which chemisorb to transition metals. This …
Heavy metals, oxidative stress, and the role of AhR signaling
Abstract The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcriptional factor
pivotal in responding to environmental stress and maintaining cellular homeostasis …
pivotal in responding to environmental stress and maintaining cellular homeostasis …
Mode of action and dose–response framework analysis for receptor-mediated toxicity: the aryl hydrocarbon receptor as a case study
RA Budinsky, D Schrenk, T Simon… - Critical reviews in …, 2014 - Taylor & Francis
Dioxins and dioxin-like compounds are tumor promoters that cause liver cancer in rats and
mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this …
mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this …
The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
ME Hahn, AG McArthur, SI Karchner, DG Franks… - PloS one, 2014 - journals.plos.org
Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis
and to cardiovascular and neurodegenerative diseases. Developing animals may be …
and to cardiovascular and neurodegenerative diseases. Developing animals may be …