[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030

B Vogel, M Acevedo, Y Appelman, CNB Merz… - The Lancet, 2021 - thelancet.com
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

G Hajishengallis - Periodontology 2000, 2022 - Wiley Online Library
Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus,
is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive …

[HTML][HTML] More treatment but no less depression: The treatment-prevalence paradox

J Ormel, SD Hollon, RC Kessler, P Cuijpers… - Clinical psychology …, 2022 - Elsevier
Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …

[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications

D De Ridder, D Adhia, S Vanneste - Neuroscience & Biobehavioral …, 2021 - Elsevier
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

[HTML][HTML] Precision medicine in the era of artificial intelligence: implications in chronic disease management

M Subramanian, A Wojtusciszyn, L Favre… - Journal of translational …, 2020 - Springer
Aberrant metabolism is the root cause of several serious health issues, creating a huge
burden to health and leading to diminished life expectancy. A dysregulated metabolism …

[HTML][HTML] Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury: a double-blind, placebo-controlled, randomized clinical trial

FX Guyette, JB Brown, MS Zenati, BJ Early-Young… - JAMA …, 2021 - jamanetwork.com
Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Artificial intelligence in psychiatry research, diagnosis, and therapy

J Sun, QX Dong, SW Wang, YB Zheng, XX Liu… - Asian Journal of …, 2023 - Elsevier
Psychiatric disorders are now responsible for the largest proportion of the global burden of
disease, and even more challenges have been seen during the COVID-19 pandemic …