Introduction 3. Molecular basis of RyR2 redox regulation 3.1. Nitric Oxide Synthases and
RyR2 S-Nitrosylation 3.1. 1. Localization and function of NOS isoforms in cardiac myocytes …

Ca+ mishandling due to impaired activity of cardiac sarco (endo) plasmic reticulum Ca2+
ATPase (SERCA2a) has been associated with the development of left ventricular diastolic …

Optical mapping of cardiac excitation using voltage-and calcium-sensitive dyes has allowed
a unique view into excitation wave dynamics, and facilitated scientific discovery in the …

Rationale: Repolarization alternans (RA) are associated with arrhythmogenesis. Animal
studies have revealed potential mechanisms, but human-focused studies are needed. RA …

Cardiac alternans is a recognized risk factor for cardiac arrhythmia and sudden cardiac
death. At the cellular level, Ca2+ alternans appears as cytosolic Ca2+ transients of …

Prolongation of the Ca2+ transient and action potential (AP) durations are two characteristic
changes in myocyte physiology in the failing human heart. The hypothesis of this study is …

New Findings What is the topic of this review? This review considers the factors that regulate
the systolic Ca transient in cardiac muscle and how disturbed Ca signalling can result in …

Calcium alternans is associated with T-wave alternans and pulsus alternans, harbingers of
increased mortality in the setting of heart disease. Recent experimental, computational, and …

Detubulation of rat ventricular myocytes has been used to investigate the role of the t-tubules
in Ca2+ cycling during excitation-contraction coupling in rat ventricular myocytes. Ca2+ was …

Ca2+ alternans is a potentially arrhythmogenic beat‐to‐beat alternation of the amplitude of
the action potential‐induced [Ca2+] i transient in cardiac myocytes. Despite its …