In cardiac cells, the coupling between the voltage across the cell membrane (V m) and the
release of calcium (Ca) from intracellular stores is a crucial ingredient of heart function …

Using biochemical/pharmacological approaches, we previously showed that type 2
ryanodine receptors (RyR2) become dysfunctional in hearts of streptozotocin-induced type 1 …

We have characterized modulation of I Ca by Ca2+ at the t-tubules (ie, in control cells) and
surface sarcolemma (ie, in detubulated cells) of cardiac ventricular myocytes, using the …

The cardiac voltage gated Ca 2+ current (I Ca) is critical to the electrophysiological
properties, excitation-contraction coupling, mitochondrial energetics, and transcriptional …

Optical mapping studies have suggested that intracellular Ca2+ and T-wave alternans are
linked through underlying alternations in Ca2+ cycling-inducing oscillations in action …

The action potential of cardiac ventricular myocytes is characterized by its long duration,
mainly due to Ca flux through L-type Ca channels. Ca entry also serves to trigger the release …

Abstract Intracellular calcium (Ca2+) alternans is a dynamical phenomenon in ventricular
myocytes, which is linked to the genesis of lethal arrhythmias. Iterated map models of …

Myocardial infarction (MI) can result in sympathetic nerve loss in the infarct region. However,
the contribution of hypo-innervation to electrophysiological remodeling, independent from MI …

Experimentally based models of the heart have been developed since 1960, starting with
the discovery and modelling of potassium channels. The early models were based on …

T-wave alternans (TWA), an ABAB oscillation, has been postulated as the initial pattern in a
stepwise progression to higher-order oscillations, culminating in sudden arrhythmic death …