The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and
recurrent course, which significantly reduces the quality of life. Sleep disturbances are …

Leydig cells play a critical role in male reproductive physiology, and their dysfunction is
usually associated with male infertility. Melatonin has an important protective and regulatory …

Melatonin, an endogenous hormone, plays protective roles in cancer. In addition to
regulating circadian rhythms, sleep, and neuroendocrine activity, melatonin functions in …

The corpus luteum is primarily responsible for the production and secretion of progesterone.
Melatonin has been established to regulate autophagy and induce progesterone secretion …

Simple Summary Melatonin is a hormone known for regulating the sleep–wake cycle and as
an indicator of the photoperiod in seasonally reproducing mammals. Its direct role in ovarian …

Melatonin (MT) is a bio-antioxidant that has been widely used to prevent pregnancy
complications, such as pre-eclampsia and IUGR during gestation. This experiment …

Agomelatine is a pharmaceutical compound that functions as an agonist for melatonin
receptors, with a particular affinity for the MT1 and MT2 receptor subtypes. Its mode of action …

In the current study, using Aanat and Mt2 KO mice, we observed that the preservation of the
melatonergic system is essential for successful early pregnancy in mice. We identified that …

Simple Summary Arylalkylamine N-acetyltransferase (AANAT) is an enzyme that regulates
the production of melatonin, a hormone that is essential for organisms to maintain circadian …