The changing therapeutic landscape of head and neck cancer

JD Cramer, B Burtness, QT Le, RL Ferris - Nature reviews Clinical …, 2019 - nature.com
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …

Optimizing treatment de‐escalation in head and neck cancer: current and future perspectives

AJ Rosenberg, EE Vokes - The oncologist, 2021 - academic.oup.com
Abstract Treatment of locoregionally advanced head and neck squamous cell carcinoma
involves a multidisciplinary approach that combines surgery, radiotherapy, and systemic …

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

R Lin, Z Zhang, L Chen, Y Zhou, P Zou, C Feng… - Cancer letters, 2016 - Elsevier
Head and neck cancer is the sixth most common cancer worldwide. Dihydroartemisinin
(DHA), a semi-synthetic derivative of artemisinin, exhibits a wide range of biological roles …

[HTML][HTML] ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance

Y Sun, Y Qiao, Y Liu, J Zhou, X Wang, H Zheng, Z Xu… - Redox biology, 2021 - Elsevier
Reactive oxygen species (ROS) induction is an effective mechanism to kill cancer cells for
many chemotherapeutics, while resettled redox homeostasis induced by the anticancer …

The role of computer aided design/computer assisted manufacturing (CAD/CAM) and 3-dimensional printing in head and neck oncologic surgery: A review and future …

SC Nyirjesy, M Heller, N von Windheim, A Gingras… - Oral oncology, 2022 - Elsevier
Microvascular free flap reconstruction has remained the standard of care in reconstruction of
large tissue defects following ablative head and neck oncologic surgery, especially for bony …

Combination of ipilimumab and nivolumab in cancers: from clinical practice to ongoing clinical trials

O Kooshkaki, A Derakhshani, N Hosseinkhani… - International journal of …, 2020 - mdpi.com
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1
(PD-1) are inhibitory checkpoints that are commonly seen on activated T cells and have …

The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer

L Liu, MA Lim, SN Jung, C Oh, HR Won, YL Jin, Y Piao… - Phytomedicine, 2021 - Elsevier
Background Despite recent advances in understanding the complex immunologic
dysfunction in the tumor microenvironment (TME), fewer than 20% of patients with head and …

Risk of active tuberculosis in patients with cancer: a systematic review and metaanalysis

MP Cheng, CNA Chakra, CP Yansouni… - Clinical Infectious …, 2017 - academic.oup.com
Background. Cancer is a known risk factor for developing active tuberculosis. We
determined the incidence and relative risk of active tuberculosis in cancer patients …

Reactivation of tuberculosis in cancer patients following administration of immune checkpoint inhibitors: current evidence and clinical practice recommendations

A Anastasopoulou, DC Ziogas, M Samarkos… - … for immunotherapy of …, 2019 - Springer
Immune checkpoint inhibitors (ICBs) have revolutionized cancer treatment producing
remarkable and durable responses for a range of malignancies. However, the additional …

Efficacy of Melatonin in prevention of radiation‐induced oral mucositis: A randomized clinical trial

HH Elsabagh, E Moussa, SA Mahmoud… - Oral …, 2020 - Wiley Online Library
Objectives Evaluating the effectiveness of melatonin in prevention of radiation‐induced oral
mucositis. Material and methods A randomized controlled clinical study was conducted on …