The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have
diverse pharmacological activities against human ailments including neurological diseases …

Despite numerous efforts to identify specific and sensitive biomarkers, the diagnosis of
Parkinson's disease (PD) is still based on clinical criteria that include the presence of a …

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Parkinson's disease (PD) is the second most common neurodegenerative disorder.
Although its major manifestation is motor symptoms, resulting from the loss of dopaminergic …

Apart from its role in motor coordination, the importance of the cerebellum in cognitive and
affective processes has been recognized in the past few decades. Spinocerebellar ataxias …

The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy,
beginning in caudal brainstem that later spreads rostrally. However, the primarily subcortical …

Abstract Purpose People with Parkinson's disease (hereafter Parkinson's) can experience
stigma through the attitudes and actions of others (enacted stigma) and through anticipation …

Medications that improve pain threshold can be useful in the pharmacotherapy of
Parkinson's disease (PD). Pain is a prevalent PD's non-motor symptom with a higher …

Background A number of non-motor symptoms occurs in Parkinson Disease (PD), cognitive
decline and mood disturbances representing the most prevalent. Recent studies reported …