Tuberculosis (TB) is one of the deadly diseases caused by Mycobacterium tuberculosis
(Mtb), which presents a significant public health challenge. Treatment of TB relies on the …

In the present work three novel copper (II) complexes ([CuL (CH 3 COO)](1),[CuL (phen)](2)
and [CuL (bpy)](3)(where phen= 1, 10-phenanthroline; bpy= 2, 2′ bipyridyl)) containing 3 …

Tuberculosis caused by Mycobacterium tuberculosis (M. tb) has killed millions worldwide.
Antibiotic resistance leads to the ineffectiveness of the current therapies. Aminoacyl tRNA …

A series of twelve novel hybrids of cinnamic acid and thiocarbohydrazones were designed,
synthesized in high yield using a simple coupling strategy via acid chlorides, and evaluated …

Antimicrobial resistance (AMR), especially bacterial AMR, poses a global threat to public
health and has become a huge obstacle to the effective control of related infectious …

Coinfections with pathogens that have opportunistic or synergistic mechanisms of action
pose important clinical challenges. Treatment of dual infections can be hampered by …

In recent past, repurposing and subsequent medicinal chemistry efforts on anti‐obesity drug
rimonabant has successfully delivered several pyrroles and pyrazole‐based hits active …

Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is responsible for the highest
global health problem, with the deaths of millions of people. With prevalence of multiple drug …

Tuberculosis remains a global health problem that affects millions of people around the
world. Despite recent efforts in drug development, new alternatives are required. Herein, a …

The growth of resistance to antimycobacterial drugs dictates the need to develop new
agents with high therapeutic efficacy and low toxicity. The present review analyzes and …