Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

[HTML][HTML] Copper in cancer: from pathogenesis to therapy

D Guan, L Zhao, X Shi, X Ma, Z Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …

Extracellular matrix regulation in physiology and in brain disease

A Soles, A Selimovic, K Sbrocco, F Ghannoum… - International journal of …, 2023 - mdpi.com
The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

[HTML][HTML] Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening

X Deng, T Liu, Y Zhu, J Chen, Z Song, Z Shi, H Chen - Bioactive Materials, 2024 - Elsevier
Limited by low tumor immunogenicity and the immunosuppressive tumor microenvironment
(TME), triple-negative breast cancer (TNBC) has been poorly responsive to immunotherapy …

Covalent organic framework nanoparticles: Overcoming the challenges of hypoxia in cancer therapy

N Singh, M Won, Y Xu, C Yoon, J Yoo, M Li… - Coordination Chemistry …, 2024 - Elsevier
Hypoxia, or low oxygen levels, is a common feature of the tumor microenvironment. It is
caused by the aggressive proliferation of cancer cells, which consume more oxygen than …

Cancer Stem‐Like Cells‐Oriented Surface Self‐Assembly to Conquer Radioresistance

Q Wang, H Cao, X Hou, D Wang, Z Wang… - Advanced …, 2023 - Wiley Online Library
Cancer stem‐like cells (CSCs), capable of indefinite self‐renewal and differentiation, are
considered to be the root cause of tumor radiotherapy (RT) resistance. However, the CSCs …

Role of oxidative stress in metabolic reprogramming of brain cancer

K Agrawal, S Asthana, D Kumar - Cancers, 2023 - mdpi.com
Simple Summary According to Globocan 2020 data, approximately 308,102 new cases of
brain cancer and central nervous system (CNS) cancers were reported worldwide, with …

Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression

Q Meng, H Sun, Y Zhang, X Yang, S Hao, B Liu… - Journal of Experimental …, 2024 - Springer
Abstract Background Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is
identified as an oncogene involved in multiple regulation of tumor progression, but specific …

Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

L Pang, S Guo, F Khan, M Dunterman, H Ali, Y Liu… - Cell Reports …, 2023 - cell.com
Glioblastoma (GBM) is a hypoxic and" immune-cold" tumor containing rich stromal signaling
molecules and cell populations, such as proteases and immunosuppressive tumor …