The initial stages of animal virus infection are generally described as the binding of free
virions to permissive target cells followed by entry and replication. Although this route of …

One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …

Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but
whether this interaction has physiological consequences on DC function is largely …

T-cell exhaustion, originally described in chronic viral infections, was recently reported in
solid and hematologic cancers. It is not defined whether exhaustion contributes to T-cell …

Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined.
Here we demonstrate that impaired actin polymerization results in CD4+ and CD8+ T cells …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

Retroviruses have evolved effective strategies to evade the host immune response, such as
high variability and latent infection. In addition, primate lentiviruses, such as HIV-1, have …

The virus HTLV-1 is thought to pass between cells through synapses formed when infected
lymphocytes make contact with other T cells. Isabelle Thoulouze and her colleagues …

Contact-dependent communication between immune cells generates protection but also
facilitates viral spread. Here we found that macrophages formed long-range actin-propelled …

Cells use a variety of intercellular structures, including gap junctions and synapses, for cell–
cell communication. Here, we present recent advances in the understanding of thin …