[HTML][HTML] MRD tailored therapy in AML: what we have learned so far

LL Ngai, A Kelder, JJWM Janssen… - Frontiers in …, 2021 - frontiersin.org
Acute myeloid leukemia (AML) is a heterogeneous clonal disease associated with a dismal
survival, partly due to the frequent occurrence of relapse. Many patient-and leukemia …

[HTML][HTML] Dose intensity for conditioning in allogeneic hematopoietic cell transplantation: can we recommend “when and for whom” in 2021?

N Gagelmann, N Kröger - Haematologica, 2021 - ncbi.nlm.nih.gov
Allogeneic hematopoietic stem-cell transplantation is a potentially curative therapy for
various hematologic diseases. An essential component of this procedure is the pre …

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

NR Mathew, F Baumgartner, L Braun, D O'Sullivan… - Nature medicine, 2018 - nature.com
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …

[HTML][HTML] Haploidentical allograft is superior to matched sibling donor allograft in eradicating pre-transplantation minimal residual disease of AML patients as …

YJ Chang, Y Wang, YR Liu, LP Xu, XH Zhang… - Journal of hematology & …, 2017 - Springer
Background This study compared the effects of pre-transplantation minimal residual disease
(pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched …

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

FM Uhl, S Chen, D O'Sullivan… - Science translational …, 2020 - science.org
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation
(allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after …

[HTML][HTML] Hematopoietic stem cell transplantation for acute myeloid leukemia: a review

AA Kassim, BN Savani - Hematology/oncology and stem cell therapy, 2017 - Elsevier
Increasing numbers of patients are receiving allogeneic hematopoietic cell transplantation
(HCT) for acute myeloid leukemia (AML). Scientific and clinical advances in supportive care …

Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid …

F Fasslrinner, J Schetelig, A Burchert… - The Lancet …, 2018 - thelancet.com
Background The impact of the intensity of conditioning before allogeneic haemopoietic cell
transplantation (HCT) has been studied in a randomised phase 3 trial comparing reduced …

[HTML][HTML] Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart …

S Liao, Y Zhang, S Ting, Z Zhen, F Luo, Z Zhu… - Stem cell research & …, 2019 - Springer
Background Optimal cell type as cell-based therapies for heart failure (HF) remains unclear.
We sought to compare the safety and efficacy of direct intramyocardial transplantation of …

[PDF][PDF] Conditioning

A Nagler, A Shimoni - The EBMT handbook: hematopoietic stem …, 2019 - library.oapen.org
HSCT is a therapeutic procedure that can cure and/or prolong life in a broad range of
hematologic disorders including malignant and nonmalignant pathologies. Conditioning is …

[HTML][HTML] Conditioning regimens for allogeneic hematopoietic cell transplantation in acute myeloid leukemia: Real-world data from the Japanese registry studies

M Yanada, K Harada, Y Shimomura, Y Arai… - Frontiers in …, 2022 - frontiersin.org
Conditioning regimens play a crucial role in preventing relapse of acute myeloid leukemia
(AML) following allogeneic hematopoietic cell transplantation (HCT). In early times …