Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-
mediated immune suppression. Understanding the mechanisms leading to functional …

Mapping tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor
cells can fundamentally improve our understanding of tumor biology, facilitates the …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Lipid peroxides accumulation induced ferroptosis is an effective cell death pathway for
cancer therapy. However, the hypoxic condition of tumor microenvironment significantly …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …