Carbapenem resistance in difficult-to-treat P. aeruginosa (DTR-PA) strains is primarily
mediated by loss or reduction of the OprD porin, overexpression of the cephalosporinase …

The objective of this study was to assess the relationship between joint pharmacokinetic/
pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ceftazidime …

The swift emergence and propagation of multidrug-resistant (MDR) bacterial pathogens
constitute a tremendous global health crisis. Among these pathogens, the challenge of …

Key messages In this study including 391 critically ill patients with nosocomial pneumonia
due to Gram-negative pathogens, combination therapy was not associated with a reduced …

Background The efficacy and safety of cefiderocol in ICU patients with difficult-to-treat
resistance (DTR) non-fermenting Gram-negative bacteria (Nf-GNB) are not as well …

Multidrug-resistant Klebsiella pneumoniae (MDR-Kp) poses a looming health threat to
humans. Clinicians find difficulties in treating MDR-Kp infections in patients with severe …

Antibiotic resistance is a global public health concern that poses a significant threat to the
effective treatment of bacterial infections. Enterobacteriaceae, a family of gram-negative …

Background: According to the World Health Organization (WHO), bacterial resistance to
antibiotics is a global public health challenge, which is also developing in Niger. The aim of …

Key messages In this study including 391 critically ill patients with nosocomial pneumonia
due to Gram‑negative pathogens, combination therapy was not associated with a reduced …

Background Bloodstream infection (BSI) is associated with poor outcomes especially when
effective antimicrobial therapy and control of infection source are delayed. As the frequency …