Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …

Recent studies have revealed the regulatory potential of many long noncoding RNAs
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic
modification in living organisms; however, the biological role of Ψ remains poorly …

Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene
expression networks and exhibit a surprising range of shapes and sizes. Several distinct …

Transcription factors (TFs) bind specific sequences in promoter-proximal and-distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian
genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …