Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …

Antisense transcription, which was initially considered by many as transcriptional noise, is
increasingly being recognized as an important regulator of gene expression. It is …

Transcription and regulation of genes originate from transcription pre-initiation complexes
(PICs). Their structural and positional organization across eukaryotic genomes is unknown …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality
worldwide. Despite progress in diagnostics and treatment of HCC, its prognosis remains …

Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all
vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important …

A large proportion of functional sequence within mammalian genomes falls outside protein-
coding exons and can be transcribed into long RNAs. However, the roles in mammalian …

Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-
like phenotype, is a process co-opted by carcinoma cells in order to initiate invasion and …

The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …

Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional
promoters that synthesize mRNA and divergent noncoding RNA (ncRNA). Here, we show …

High-throughput RNA sequencing has revealed more pervasive transcription of the human
genome than previously anticipated. However, the extent of natural antisense …