Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

The failing heart is characterized by complex tissue remodelling involving increased
cardiomyocyte death, and impairment of sarcomere function, metabolic activity, endothelial …

Introduction: Cardiovascular gene therapy is the third most popular application for gene
therapy, representing 8.4% of all gene therapy trials as reported in 2012 estimates. Gene …

Human dilated cardiomyopathy (DCM) manifests as a profound reduction in biventricular
cardiac function that typically progresses to death or cardiac transplantation. There is no …

Myofilament-based physiological regulatory compensation preserves diastolic function in
failing hearts with severe Ca 2+ handlin Page 1 Myofilament-based physiological regulatory …

In failing rat hearts, post-transcriptonal inhibition of phospholamban (PLB) expression by
AAV9 vector-mediated cardiac delivery of short hairpin RNAs directed against PLB (shPLBr) …

Abstract Defective intracellular calcium (Ca 2+) handling is implicated in the pathogenesis of
heart failure. Novel approaches targeting both cardiac Ca 2+ release and reuptake …

Congestive heart failure (CHF) is a major cause of morbidity and mortality. Because its
prevalence is increasing and outlook remains dismal despite optimal medical and device …

Congestive heart failure is a major cause of morbidity and mortality with increasing social
and economic costs. There have been no new high impact therapeutic agents for this …