Can population pharmacokinetics of antibiotics be extrapolated? Implications of external evaluations

Y Cheng, C Wang, Z Li, Y Pan, M Liu, Z Jiao - Clinical pharmacokinetics, 2021 - Springer
Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …

[HTML][HTML] CDC Guidelines for the Prevention and Treatment of Anthrax, 2023

WA Bower - MMWR. Recommendations and Reports, 2023 - cdc.gov
This report updates previous CDC guidelines and recommendations on preferred
prevention and treatment regimens regarding naturally occurring anthrax. Also provided are …

Use of antibiotics in preterm newborns

R Simeoli, S Cairoli, N Decembrino, F Campi… - Antibiotics, 2022 - mdpi.com
Due to complex maturational and physiological changes that characterize neonates and
affect their response to pharmacological treatments, neonatal pharmacology is different from …

Drug clearance in neonates: a combination of population pharmacokinetic modelling and machine learning approaches to improve individual prediction

BH Tang, Z Guan, K Allegaert, YE Wu, E Manolis… - Clinical …, 2021 - Springer
Background Population pharmacokinetic evaluations have been widely used in neonatal
pharmacokinetic studies, while machine learning has become a popular approach to solving …

Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling

PJ De Sutter, P Rossignol, L Breëns, E Gasthuys… - Pharmaceutics, 2023 - mdpi.com
The volume of distribution at steady state (Vss) in neonates is still often estimated through
isometric scaling from adult values, disregarding developmental changes beyond body …

[HTML][HTML] Early life antibiotics influence in vivo and in vitro mouse intestinal epithelium maturation and functioning

TM Garcia, M van Roest, JLM Vermeulen… - Cellular and molecular …, 2021 - Elsevier
Background & Aims The use of antibiotics (ABs) is a common practice during the first months
of life. ABs can perturb the intestinal microbiota, indirectly influencing the intestinal epithelial …

Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber …

Y Zhang, WAS Aldamarany, G Song, J Liu, S Liu… - International Journal of …, 2023 - Elsevier
In this study, konjac glucomannan (KGM) and its derivatives were gavaged as dietary fiber
supplements, followed by a single dose of antibiotic cocktail (Abx) containing amoxicillin …

10‐Day and 14‐day high‐dose dual therapy for the treatment of Helicobacter pylori: A propensity score matching analysis

PY Zou, J Hu, JT Zhao, Z Zhao, H Mei, J Yang… - …, 2021 - Wiley Online Library
Background Inconsistent eradication rates for Helicobacter pylori have been reported
worldwide with dual therapy, perhaps owing to the difference in dose administration and …

Optimization of β-Lactam Dosing Regimens in Neonatal Infections: Continuous and Extended Administration versus Intermittent Administration

E Leegwater, L Wewerinke, AM de Grauw… - Clinical …, 2023 - Springer
Abstract Background and Objective In neonates, β-Lactam antibiotics are almost exclusively
administered by intermittent infusion. However, continuous or prolonged infusion may be …

Dose optimization of β-lactams antibiotics in pediatrics and adults: A systematic review

A Haseeb, HS Faidah, S Alghamdi… - Frontiers in …, 2022 - frontiersin.org
Background: β-lactams remain the cornerstone of the empirical therapy to treat various
bacterial infections. This systematic review aimed to analyze the data describing the dosing …