Background Ertapenem prophylaxis for transrectal ultrasound-guided prostate biopsy
(TRUS-PB) has proven highly effective at our institution. A subsequent study showed no …

Ceftriaxone is an antibiotic that increases central nervous system (CNS) protein expression
of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in …

Background The primary objective of this study was to compare triple therapy with
ertapenem treatments in pediatric patients with perforated appendicitis, especially in terms …

Objectives To examine the effects of exposure to ceftaroline or ceftriaxone on the epidemic
Clostridium difficile strain PCR ribotype 027 and the indigenous gut microflora in an in vitro …

Objectives Clostridium difficile infection (CDI) is still a major clinical challenge. Previous
studies have demonstrated multiple distinct C. difficile strains in the faeces of patients with …

Carbapenems are broad‐spectrum antibiotics increasingly used for the treatment of severe
infections. We evaluated the effects of four carbapenems given as monotherapies or in …

A new liquid chromatography assay with isocratic elution and tandem mass spectrometry
detection (LC–MS/MS) using an electrospray ionization interface in the multiple reaction …

Benapenem is a novel carbapenem. The objective of this study was to determine the
pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal …

The human gut microbiota has been shown to be significantly perturbed by antibiotic use,
while recovering to the pre-treatment state several weeks after short antibiotic exposure. The …

Background Cefmetazole (CMZ) is a carbapenem-sparing option in the treatment of
extended-spectrum beta-lactamase (ESBL)-producing bacterial infection. In this pilot study …