Cardiac hypertrophy is commonly observed in conditions of increased hemodynamic or
metabolic stress. This hypertrophy is not compensatory but rather reflects activation of …

O objetivo desta Diretriz é servir de apoio e auxiliar os médicos nas decisões referentes aos
seus pacientes, elaborando orientações que podem ser úteis na prática médica. A adoção …

Calcium antagonists comprise 2 main subclasses, dihydropyridines and
nondihydropyridines, and have been studied extensively in hypertensive patients. Early …

Skeletal myoblasts are an attractive cell type for transplantation because they are
autologous and resistant to ischemia. However, clinical trials of myoblast transplantation in …

L-type voltage-gated calcium channels are involved in multiple physiological functions.
Currently available antagonists do not discriminate between L-type channel isoforms …

Antagonists of L-type Ca2+ channels (LTCCs) have been used to treat human
cardiovascular diseases for decades. However, these inhibitors can have untoward effects …

Objectives: Identify the uses and indications of amlodipine; both approved and off-label.
Describe the mechanism of action of amlodipine. Summarize the adverse drug reactions of …

Aims The effectiveness of cell-based treatments for regenerative myocardial therapy is
limited by low rates of cell engraftment. Y-27632 inhibits Rho-associated protein kinase …

Decreased expression and activity of CaV1. 2 calcium channels has been reported in
pressure overload-induced cardiac hypertrophy and heart failure. However, the underlying …

The homeopathic treatment is based on the principle of therapeutic similitude, employing
medicines that cause certain disorders to treat similar manifestations, stimulating a reaction …