Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Abstract Background Patients with SARS-CoV-2 infection are at higher risk for ventilator-
associated pneumonia (VAP). No study has evaluated the relationship between VAP and …

Background There is insufficient evidence to guide ventilatory targets in acute brain injury
(ABI). Recent studies have shown associations between mechanical power (MP) and …

Background Patients with acute brain injury are at high risk of ventilator-associated
pneumonia (VAP). The benefit of short-term antibiotic prophylaxis remains debated. We …

Neuropatients often require invasive mechanical ventilation (MV). Ideal ventilator settings
and respiratory targets in neuro patients are unclear. Current knowledge suggests …

Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical
ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung …

Organ crosstalk is a complex biological communication between distal organs mediated via
cellular, soluble, and neurohormonal actions, based on a two-way pathway. The …

Although direct data to guide mechanical ventilation in brain-injured patients is
accumulating, the current evidence base remains limited. Ventilatory considerations in this …

Background Acute brain injured (ABI) patients are at high risk of developing ventilator-
associated pneumonia (VAP). However, incidence, risk factors and effects on outcome of …