Eosinophilia is common feature of many disorders, including allergic diseases. There are
many factors that influence the production, migration, survival and death of the eosinophil …

TREATMENT OF INFLAMMATORY DISEASE important. Glucocorticosteroids inhibit the
transcription of several cytokines and chemokines that Inflammation is a central feature of …

Background: Although glucocorticoids are the most effective treatment for chronic
inflammatory diseases, such as asthma, some patients show a poor response. IL-2 …

Bronchial asthma and COPD (chronic obstructive pulmonary disease) are obstructive
pulmonary diseases that affected millions of people all over the world. Asthma is a serious …

Objectives To assess the effect of montelukast versus salmeterol added to inhaled
fluticasone propionate on asthma exacerbation in patients whose symptoms are …

Previous studies have shown that the regular administration of short acting β-agonists can
be associated with adverse effects on airway caliber and bronchial hyperresponsiveness …

Asthma was previously defined as an allergic Th2‐mediated inflammatory immune disorder.
Recently, this paradigm has been challenged because not all pathological changes …

Background: Matrix metalloproteinases (MMPs) digest extracellular matrix components and
might be important mediators of tissue remodeling. Proteinase activated receptor-2 (PAR-2) …

Asthma is a very heterozygous disease, divided in subtypes, such as eosinophilic and
neutrophilic asthma. Phenotyping and endotyping of patients, especially patients with …

Advances in our understanding of allergic inflammation have led to the development of
several novel anti-inflammatory drugs that target specific aspects of the inflammatory …