In contrast to conventional hard actuators, soft actuators offer many vivid advantages, such
as improved flexibility, adaptability, and reconfigurability, which are intrinsic to living …

The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Cardiac tissues generated from human induced pluripotent stem cells (iPSCs) can serve as
platforms for patient-specific studies of physiology and disease,,,,–. However, the predictive …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Abstract Coronavirus disease 2019 (COVID-19) is a novel, highly transmittable and severe
strain disease, which has rapidly spread worldwide. Despite epidemiological evidence …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …