Recent developments in antimalarial activities of 4-aminoquinoline derivatives
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …
degeneration of the central nervous system, resulting in memory loss and cognitive …
New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
A brief overview of classical natural product drug synthesis and bioactivity
G Li, M Lou, X Qi - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Traditional medicines consisting of compounds derived from natural organisms have been
used for human health care worldwide since ancient times. Since the last century, huge …
used for human health care worldwide since ancient times. Since the last century, huge …
[HTML][HTML] Potential of nanoformulations in malaria treatment
JB Chaves, B Portugal Tavares de Moraes… - Frontiers in …, 2022 - frontiersin.org
Malaria is caused by the protozoan Plasmodium sp and affects millions of people worldwide.
Its clinical form ranges from asymptomatic to potentially fatal and severe. Current treatments …
Its clinical form ranges from asymptomatic to potentially fatal and severe. Current treatments …
In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy
IO Evbuomwan, OO Alejolowo, TC Elebiyo… - Journal of …, 2024 - Taylor & Francis
The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …
significantly threatens global health. This factor heightens the urgency to explore bioactive …
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria …
Malaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
[HTML][HTML] Design, synthesis, and biological evaluation of morpholinopyrimidine derivatives as anti-inflammatory agents
Here, we outline the synthesis of a few 2-methoxy-6-((4-(6-morpholinopyrimidin-4-yl)
piperazin-1-yl)(phenyl) methyl) phenol derivatives and assess their anti-inflammatory activity …
piperazin-1-yl)(phenyl) methyl) phenol derivatives and assess their anti-inflammatory activity …
[HTML][HTML] Estimation of pediatric dosage of antimalarial drugs, using pharmacokinetic and physiological approach
EKG Mhango, BS Snorradottir, BHK Kachingwe… - Pharmaceutics, 2023 - mdpi.com
Most of the individuals who die of malaria in sub–Saharan Africa are children. It is, therefore,
important for this age group to have access to the right treatment and correct dose …
important for this age group to have access to the right treatment and correct dose …