A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
The rapid repurposing of antivirals is particularly pressing during pandemics. However,
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
COVID-19: Discovery, diagnostics and drug development
T Asselah, D Durantel, E Pasmant, G Lau… - Journal of …, 2021 - Elsevier
Summary Coronavirus disease 2019 (COVID-19) started as an epidemic in Wuhan in 2019,
and has since become a pandemic. Groups from China identified and sequenced the virus …
and has since become a pandemic. Groups from China identified and sequenced the virus …
Chest CT in COVID-19: what the radiologist needs to know
TC Kwee, RM Kwee - Radiographics, 2020 - pubs.rsna.org
Chest CT has a potential role in the diagnosis, detection of complications, and
prognostication of coronavirus disease 2019 (COVID-19). Implementation of appropriate …
prognostication of coronavirus disease 2019 (COVID-19). Implementation of appropriate …
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …
multiple organ systems including the central nervous system (CNS). Yet, there is no …
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Abstract Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
Monocytes and Macrophages in COVID-19
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …
pandemic with massive global health and socioeconomic consequences. The disease is …
[HTML][HTML] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …
COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
AC Borczuk, SP Salvatore, SV Seshan, SS Patel… - Modern …, 2020 - nature.com
Abstract SARS-CoV-2, the etiologic agent of COVID-19, is a global pandemic with
substantial mortality dominated by acute respiratory distress syndrome. We systematically …
substantial mortality dominated by acute respiratory distress syndrome. We systematically …