Viruses infect all kingdoms of life; their genomes vary from DNA to RNA and in size from 2kB
to 1 MB or more. Viruses frequently employ disordered proteins, that is, protein products of …

Atomistic-level understanding of surface hydration mediating protein–protein interactions
and ligand binding has been a challenge due to the dynamic nature of water molecules near …

Five new series of pyrrolo-fused heterocycles were designed through a scaffold
hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin …

Bacteriophages offer a sustainable alternative for controlling crop disease. However, the
lack of knowledge on phage infection mechanisms makes phage-based biological control …

Little is known about the causes and mechanisms of ectopic immune responses, including
different types of hypersensitivity, superantigens, and cytokine storms. Two of the most …

Inflammation processes of the central nervous system (CNS) play a vital role in the
pathogenesis of several neurological and psychiatric disorders like depression. These …

Active targeting is a prospective strategy for controlled drug delivery to malignant tumor
tissues. One of the approaches relies on recognition of a bioactive ligand by a receptor …

Viral proteins frequently mutate to evade or antagonize host innate immune responses, yet
the impact of these mutations on the molecular energy landscape remains unclear …

The Epstein-Barr virus (EBV) and Kaposi's Sarcoma-associated herpesvirus (KSHV) are
prevalent worldwide with a 95% infection rate for EBV and as high as 50% for KSHV in …

The nonstructural protein 1 (NS1) of the 1918 Spanish influenza A virus hijacks N-terminal
Src-homology 3 (nSH3) domain of host's cellular CrkII with exceptionally high affinity through …