Nucleic acid therapeutics have emerged as one of the very advanced and efficacious
treatment approaches for debilitating health conditions, including those diseases affecting …

Tetramethylpyrazine (TMP) has been studied in depth and is widely used in the treatment of
many kinds of diseases in China. However, whether it has neuroprotective effects on …

Nanoparticle technologies offer a non-invasive means to deliver basic fibroblast growth
factor (bFGF) for the treatment of spinal cord injury (SCI). However, the inability of bFGF to …

The complexity and overall burden of Parkinson's disease (PD) require new
pharmacological approaches to counteract the symptomatology while reducing the …

In view of the fact that the blood–brain barrier (BBB) prevents the transport of imaging
probes and therapeutic agents to the brain and thus hinders the diagnosis and treatment of …

Glioblastoma (GBM) is the most aggressive malignant brain tumor in adults. Improvements
in the treatment of GBM have remained static since the advent of the standard therapy which …

Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor
drug transportation across the blood–brain barrier and the existence of glioma stem cells …

Aim: To improve the drug delivery to the brain with borneol (Bo)-modified solid lipid
nanoparticles (SLNs) of pueraria flavones (PTF) via intranasal administration. Materials & …

Targeted treatment of cerebral ischemia/reperfusion injury (CIRI) remains a problem due to
the difficulty in drug delivery across the blood–brain barrier (BBB). In this study, we …

Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of
ischemic stroke. Flavonoids are a broad family of plant polyphenols which are abundant in …