Severe sudden focal CnS damage that occurs following stroke, traumatic spinal cord injury
(SCi) or brain injury (tbi) in humans causes irreversible destruction of neural circuitry, often …

血脑屏障(blood-brain barrier, BBB) 是中枢神经系统内的一种特殊结构, 其优良的屏障特性能够
保护大脑免于血液循环中有害大分子及病原体的侵害. 然而, 这一屏障同时也限制了药物递送的 …

The drug discovery and development processes are divided into different stages separated
by milestones to indicate that significant progress has been made and that certain criteria for …

Blood brain barrier is considered as the physiological barrier that restricts the entry of
molecules into the central nervous system. The drug delivery mechanisms across blood …

Background: Lipid nanoparticles have been studied mainly as a means of transporting and
releasing drugs. A special emphasis has been placed on designing nanoparticles that …

Neuropathic pain is a chronic neurological disorder affecting millions of people around the
world. The currently available pharmacologic agents for the treatment of neuropathic pain …

In the present study the effect of pramipexole alginate nanodispersion (PAND) was studied
on the transgenic Drosophila exhibiting the PD symptoms. The PD flies were allowed to feed …

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Introduction: C 60 fullerene has received great attention as a candidate for biomedical …

Brain diseases are a major health challenge as brain drug delivery is truly hindered by the
blood-brain barrier. Therefore, targeted drug nanocarriers arise as an alternative to achieve …

Stroke, which includes two subtypes of ischemia and haemorrhage, is the second leading
cause of death globally (Wang et al., 2017). The occurrence of ischemic stroke is …