[HTML][HTML] Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artificial cycle for endometrial …

Y Zhang, L Wu, TC Li, CC Wang, T Zhang… - Reproductive Biology …, 2022 - Springer
Purpose This systematic review and meta-analysis aimed to compare the short-term
reproductive and long-term obstetric outcomes after endometrial preparations by ovarian …

[HTML][HTML] The regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface

H Liu, J Zheng, A Liao - Frontiers in Immunology, 2022 - frontiersin.org
The immune microenvironment at the maternal-fetal interface was determined by the
crosstalk between the trophoblast and maternal-derived cells, which dynamically changed …

METTL3 is essential for normal progesterone signaling during embryo implantation via m6A-mediated translation control of progesterone receptor

ZH Zheng, GL Zhang, RF Jiang… - Proceedings of the …, 2023 - National Acad Sciences
Embryo implantation, a crucial step in human reproduction, is tightly controlled by estrogen
and progesterone (P4) via estrogen receptor alpha and progesterone receptor (PGR) …

[HTML][HTML] Basic biology of hypoxic responses mediated by the transcription factor HIFs and its implication for medicine

K Hirota - Biomedicines, 2020 - mdpi.com
Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of
adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the …

[HTML][HTML] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment

T Hiraoka, Y Hirota, Y Fukui, M Gebril, T Kaku… - Scientific reports, 2020 - nature.com
Although it has been reported that uterine signal transducer and activator of transcription 3
(STAT3) is essential for embryo implantation, the exact roles of uterine epithelial and stromal …

[HTML][HTML] Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems

H Fujiwara, M Ono, Y Sato, K Imakawa, T Iizuka… - International Journal of …, 2020 - mdpi.com
Embryo implantation in the uterus is an essential process for successful pregnancy in
mammals. In general, the endocrine system induces sufficient embryo receptivity in the …

Current perspectives on endometrial receptivity: A comprehensive overview of etiology and treatment

T Hiraoka, Y Osuga, Y Hirota - Journal of Obstetrics and …, 2023 - Wiley Online Library
Recurrent implantation failure (RIF) remains a challenging problem in assisted reproductive
technology (ART). Further insights into uterine abnormalities that can disturb embryo …

[HTML][HTML] The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion

Y Fukui, Y Hirota, S Aikawa, A Sakashita… - Cell Death & …, 2023 - nature.com
Infertility occurs in 15% of couples worldwide. Recurrent implantation failure (RIF) is one of
the major problems in in vitro fertilization and embryo transfer (IVF–ET) programs, and how …

[HTML][HTML] Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental …

A Yaghoobi, Y Nazerian, AZ Meymand… - Frontiers in Cell and …, 2023 - frontiersin.org
Assisted reproductive techniques as a new regenerative medicine approach have
significantly contributed to solving infertility problems that affect approximately 15% of …

Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment

HQ Wang, Y Liu, D Li, JY Liu, Y Jiang, Y He, JD Zhou… - Developmental Cell, 2023 - cell.com
Embryo implantation requires temporospatial maternal-embryonic dialog. Using single-cell
RNA sequencing for the uterus from 2.5 to 4.5 days post-coitum (DPC) and bulk sequencing …