Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …

Mitochondria are vital organelles in cells, regulating energy metabolism and apoptosis.
Mitochondrial transcellular transfer plays a crucial role during physiological and pathological …

Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

Neuroglioma is a complex neuroglial tumor involving dysregulation of many biological
pathways at multiple levels. Quercetin is a potent cancer therapeutic agent presented in fruit …

Acute myeloid leukemia (AML) is one of the most aggressive hematological malignancies
with a low 5-year survival rate and high rate of relapse. Developing more efficient therapies …

The bone marrow microenvironment (BMME) is a complex ecosystem that instructs and
protects hematopoietic stem cells (HSCs) and their malignant counterparts, the leukemia …

Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …

The phosphatidylinositol 3-kinase/protein kinase B (Akt)/mechanistic target of rapamycin
(PI3K/Akt/mTOR) pathway is amplified in 60–80% of patients with acute myelogenous …

Abstract Changes in cell metabolism and metabolic adaptation are hallmark features of
many cancers, including leukemia, that support biological processes involved into tumor …

Although dasatinib is effective in most imatinib mesylate (IMT)-resistant chronic myeloid
leukemia (CML) patients, the underlying mechanism of its effectiveness in eliminating …