Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and
a key player in cancer metabolism. This review is aimed at combining the mechanisms …

Transport of ions and nutrients is a core mitochondrial function, without which there would
be no mitochondrial metabolism and ATP production. Both ion homeostasis and …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with
minimal treatment options and a global rise in prevalence. PDAC is characterized by …

Background The lactate receptor GPR81 contributes to cancer development through unclear
mechanisms. Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo …

The acidic pH of the tumor microenvironment plays a critical role in driving cancer
development toward a more aggressive phenotype, but the underlying mechanisms are …

The copious metabolic acid production and-extrusion by cancer cells render poorly
vascularized regions of solid tumors highly acidic. A growing list of proton-and bicarbonate …

Background. E2F transcription factors is a family of transcription factors, and lots of studies
have shown that they play a key role in the occurrence and development of many tumors …

Cancer remains one of the most crucial human malignancies with a higher mortality rate
globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells …

Solid tumours have abnormally high intracellular [Na+]. The activity of various Na+ channels
may underlie this Na+ accumulation. Voltage-gated Na+ channels (VGSCs) have been …

Results: We found that the mRNA expression levels of E2F1/2/3/4/5/7/8 were significantly
higher in BC patients than that of control tissues. And the increased mRNA expression levels …