Sickle cell disease (SCD) predominates in sub‐Saharan Africa, East Mediterranean areas,
Middle East, and India. Nigeria, being the most populous black nation in the world, bears its …

Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …

A significant amount of attention has recently been devoted to the mechanisms involved in
hemoglobin (Hb) switching, as it has previously been established that the induction of fetal …

Sickle cell disease (SCD; ORPHA232; OMIM# 603903) is a chronic and invalidating
disorder distributed worldwide, with high morbidity and mortality. Given the disease …

Sickle cell disease (SCD) is an inherited red blood cell disorder that occurs worldwide.
Acute vaso-occlusive crisis is the main cause of hospitalization in patients with SCD. There …

Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide
distribution. Growing evidence suggests a possible involvement of complement activation in …

Objective: To summarize recently published data on the pathophysiology, diagnosis and
treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary …

Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder,
characterized by severe organ complication. Sickle bone disease (SBD) affects a large part …

In sickle cell disease, the complex scenario of vaso-occlusive crisis (VOC) typical of this
disease is clearly multifactorial and not fully understood. Cell-cell and cell-cell matrix …

A homozygous mutation in the gene for β globin, a subunit of adult hemoglobin A (HbA), is
the proximate cause of sickle cell disease (SCD). Sickle hemoglobin (HbS) shows peculiar …