Management of sickle cell disease: a review for physician education in Nigeria (sub‐saharan Africa)
AS Adewoyin - Anemia, 2015 - Wiley Online Library
Sickle cell disease (SCD) predominates in sub‐Saharan Africa, East Mediterranean areas,
Middle East, and India. Nigeria, being the most populous black nation in the world, bears its …
Middle East, and India. Nigeria, being the most populous black nation in the world, bears its …
Thrombosis and sickle cell disease
L De Franceschi, MD Cappellini… - Seminars in thrombosis …, 2011 - thieme-connect.com
Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …
[HTML][HTML] Pharmacological induction of fetal hemoglobin in β-thalassemia and sickle cell disease: An updated perspective
A significant amount of attention has recently been devoted to the mechanisms involved in
hemoglobin (Hb) switching, as it has previously been established that the induction of fetal …
hemoglobin (Hb) switching, as it has previously been established that the induction of fetal …
[HTML][HTML] New therapeutic options for the treatment of sickle cell disease
Sickle cell disease (SCD; ORPHA232; OMIM# 603903) is a chronic and invalidating
disorder distributed worldwide, with high morbidity and mortality. Given the disease …
disorder distributed worldwide, with high morbidity and mortality. Given the disease …
[HTML][HTML] Evidence of protective effects of recombinant ADAMTS13 in a humanized model of sickle cell disease
P Rossato, E Federti, H Glantschnig, F Canneva… - …, 2022 - ncbi.nlm.nih.gov
Sickle cell disease (SCD) is an inherited red blood cell disorder that occurs worldwide.
Acute vaso-occlusive crisis is the main cause of hospitalization in patients with SCD. There …
Acute vaso-occlusive crisis is the main cause of hospitalization in patients with SCD. There …
[HTML][HTML] Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule
Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide
distribution. Growing evidence suggests a possible involvement of complement activation in …
distribution. Growing evidence suggests a possible involvement of complement activation in …
[HTML][HTML] The genetics of blood disorders: hereditary hemoglobinopathies
Objective: To summarize recently published data on the pathophysiology, diagnosis and
treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary …
treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary …
Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease
LD Carbonare, A Matte', MT Valenti… - Blood, The Journal …, 2015 - ashpublications.org
Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder,
characterized by severe organ complication. Sickle bone disease (SBD) affects a large part …
characterized by severe organ complication. Sickle bone disease (SBD) affects a large part …
Erythroid adhesion molecules in sickle cell disease: effect of hydroxyurea
JP Cartron, J Elion - Transfusion clinique et biologique, 2008 - Elsevier
In sickle cell disease, the complex scenario of vaso-occlusive crisis (VOC) typical of this
disease is clearly multifactorial and not fully understood. Cell-cell and cell-cell matrix …
disease is clearly multifactorial and not fully understood. Cell-cell and cell-cell matrix …
[HTML][HTML] Pathophisiology of sickle cell disease and new drugs for the treatment
L De Franceschi - … Journal of Hematology and Infectious Diseases, 2009 - ncbi.nlm.nih.gov
A homozygous mutation in the gene for β globin, a subunit of adult hemoglobin A (HbA), is
the proximate cause of sickle cell disease (SCD). Sickle hemoglobin (HbS) shows peculiar …
the proximate cause of sickle cell disease (SCD). Sickle hemoglobin (HbS) shows peculiar …