Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …

Simple Summary The term hypoxia is used to describe biological situations where
insufficient levels of oxygen exist. Hypoxia and hypoxic states can occur in a range of …

A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts
radiotherapy. As a result, there has been longstanding active research into novel methods of …

Summary Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes
in O 2 concentration. O 2-dependent degradation of the HIF-1α subunit is mediated by prolyl …

Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …

Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of
cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type …

Chronic inflammation has emerged as one of the hallmarks of cancer. Inflammation also
plays a pivotal role in modulating radiation responsiveness of tumors. As discussed in this …

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

Hypoxia exists in solid tumor tissues due to abnormal vasculature, vascular insufficiency,
treatment or malignancy related anemia, and low intratumor blood flow. Hypoxic status in …