Exosomal transmission of viruses, a two-edged biological sword

N Mardi, S Haiaty, R Rahbarghazi, H Mobarak… - Cell Communication and …, 2023 - Springer
As a common belief, most viruses can egress from the host cells as single particles and
transmit to uninfected cells. Emerging data have revealed en bloc viral transmission as lipid …

Thermal-controlled cellular uptake of “hot” nanoparticles

H Chen, X Dong, L Ou, C Ma, B Yuan, K Yang - Nanoscale, 2023 - pubs.rsc.org
Nanoparticles (NPs) have shown immense potential in the field of biomedical applications,
particularly in NP-based photothermal therapy, which offers a remote-controlled approach to …

Membrane-specific binding of 4 nm lipid nanoparticles mediated by an entropy-driven interaction mechanism

L Ou, H Chen, B Yuan, K Yang - ACS nano, 2022 - ACS Publications
Lipid nanoparticles (LNPs) are a leading biomimetic drug delivery platform due to their
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …

Interplay of receptor-ligand binding and lipid domain formation during cell adhesion

L Li, J Hu, B Różycki, J Ji, F Song - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Cell adhesion involved in biological processes such as cell migration, immune responses,
and cancer metastasis, is mediated by the specific binding of receptor and ligand proteins …

Synergistic entry of individual nanoparticles into mammalian cells driven by free energy decline and regulated by their sizes

Y Wei, H Chen, YX Li, K He, K Yang, HB Pang - ACS nano, 2022 - ACS Publications
Cell entry is one of the common prerequisites for nanomaterial applications. Despite
extensive studies on a homogeneous group of nanoparticles (NPs), fewer studies have …

Co-Administration of transportan peptide enhances the cellular entry of liposomes in the bystander manner both in vitro and in vivo

YX Li, N Wang, MM Hasan, HB Pang - Molecular pharmaceutics, 2022 - ACS Publications
Liposomes have been widely used as a drug delivery vector. One way to further improve its
therapeutic efficacy is to increase the cell entry efficiency. Covalent conjugation with cell …

Simultaneous exposure of different nanoparticles influences cell uptake

I de Boer, CJ Richards, C Åberg - Pharmaceutics, 2022 - mdpi.com
Drug delivery using nano-sized carriers holds tremendous potential for curing a range of
diseases. The internalisation of nanoparticles by cells, however, remains poorly understood …

Insight into biophysicochemical principles of biopolymers through simulation and theory

HX Wan, D Xu, XW Dong, K Yang, LT Yan - Chinese Journal of Polymer …, 2023 - Springer
The development of biopolymers for biomedical applications has traditionally been based
on new chemistries. However, there is growing recognition that the biological responses can …

Nanoparticle delivery of active traditional Chinese medicine ingredients: A new strategy for the treatment of liver cancer

M Wang, P Peng, Z Chen… - Current Pharmaceutical …, 2023 - ingentaconnect.com
The precise treatment of liver cancer is receiving much research attention. Surgery,
chemoradiotherapy, and other methods remain the mainstream of this treatment, but many …

Selective membrane wrapping on differently sized nanoparticles regulated by clathrin assembly: A computational model

Y Li, M Zhang, X Niu, T Yue - Colloids and Surfaces B: Biointerfaces, 2022 - Elsevier
Nanoparticles (NPs) enter cells via multiple pathways, all of which are NP size dependent.
Previous studies indicated that the clathrin-mediated endocytosis has different selectivity for …