[HTML][HTML] Convergent evolution in SARS-CoV-2 spike creates a variant soup from which new COVID-19 waves emerge
The first 2 years of the COVID-19 pandemic were mainly characterized by recurrent
mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 …
mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 …
[HTML][HTML] Recombination in Coronaviruses, with a Focus on SARS-CoV-2
Recombination is a common evolutionary tool for RNA viruses, and coronaviruses are no
exception. We review here the evidence for recombination in SARS-CoV-2 and reconcile …
exception. We review here the evidence for recombination in SARS-CoV-2 and reconcile …
[HTML][HTML] Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
[HTML][HTML] BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage 1. The receptor …
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage 1. The receptor …
[HTML][HTML] Outbreak. info genomic reports: scalable and dynamic surveillance of SARS-CoV-2 variants and mutations
K Gangavarapu, AA Latif, JL Mullen, M Alkuzweny… - Nature …, 2023 - nature.com
In response to the emergence of SARS-CoV-2 variants of concern, the global scientific
community, through unprecedented effort, has sequenced and shared over 11 million …
community, through unprecedented effort, has sequenced and shared over 11 million …
[HTML][HTML] Characterization of the enhanced infectivity and antibody evasion of Omicron BA. 2.75
Summary Recently emerged SARS-CoV-2 Omicron subvariant, BA. 2.75, displayed a growth
advantage over circulating BA. 2.38, BA. 2.76, and BA. 5 in India. However, the underlying …
advantage over circulating BA. 2.38, BA. 2.76, and BA. 5 in India. However, the underlying …
[HTML][HTML] Enhanced evasion of neutralizing antibody response by Omicron XBB. 1.5, CH. 1.1, and CA. 3.1 variants
P Qu, JN Faraone, JP Evans, YM Zheng, C Carlin… - Cell reports, 2023 - cell.com
Omicron subvariants continuingly challenge current vaccination strategies. Here, we
demonstrate nearly complete escape of the XBB. 1.5, CH. 1.1, and CA. 3.1 variants from …
demonstrate nearly complete escape of the XBB. 1.5, CH. 1.1, and CA. 3.1 variants from …
[HTML][HTML] A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
[HTML][HTML] Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
AK Reuschl, LG Thorne, MVX Whelan… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
Immune evasion and membrane fusion of SARS-CoV-2 XBB subvariants EG. 5.1 and XBB. 2.3
JN Faraone, P Qu, N Goodarzi, YM Zheng… - Emerging Microbes & …, 2023 - Taylor & Francis
Immune evasion by SARS-CoV-2 paired with immune imprinting from monovalent mRNA
vaccines has resulted in attenuated neutralizing antibody responses against Omicron …
vaccines has resulted in attenuated neutralizing antibody responses against Omicron …