Hepatocellular carcinoma in the setting of alcohol-related liver disease
N Ganne-Carrié, P Nahon - Journal of hepatology, 2019 - Elsevier
Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis
AG Singal, H Manjunath, AC Yopp… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote
nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and …
nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and …
Carriage of the PNPLA3 rs738409 C> G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
YL Liu, GL Patman, JBS Leathart, AC Piguet… - Journal of …, 2014 - Elsevier
Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …
[PDF][PDF] PNPLA3, CGI‐58, and inhibition of hepatic triglyceride hydrolysis in mice
A variant (148M) in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is a
major risk factor for fatty liver disease. Despite its clinical importance, the pathogenic …
major risk factor for fatty liver disease. Despite its clinical importance, the pathogenic …
Genetic factors that affect risk of alcoholic and nonalcoholic fatty liver disease
Genome-wide association studies and candidate gene studies have informed our
understanding of factors contributing to the well-recognized interindividual variation in the …
understanding of factors contributing to the well-recognized interindividual variation in the …
Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins
A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …
polytopic protein of unknown function, is associated with the full spectrum of fatty liver …
The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum that spans simple
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …
Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment
P Dongiovanni, QM Anstee… - Current pharmaceutical …, 2013 - ingentaconnect.com
Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver
disease (NAFLD) which, when associated with oxidative hepatocellular damage …
disease (NAFLD) which, when associated with oxidative hepatocellular damage …
PNPLA3 gene in liver diseases
Genome-wide association studies (GWAS) in the field of liver diseases have revealed
previously unknown pathogenic loci and generated new biological hypotheses. In 2008, a …
previously unknown pathogenic loci and generated new biological hypotheses. In 2008, a …
[PDF][PDF] Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta‐analysis of individual participant data
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries.
Although several clinical factors have been identified, many individuals never develop HCC …
Although several clinical factors have been identified, many individuals never develop HCC …