[HTML][HTML] Exploring the chemical space of orally bioavailable PROTACs
A principal challenge in the discovery of proteolysis targeting chimeras (PROTACs) as oral
medications is their bioavailability. To facilitate drug design, it is therefore essential to …
medications is their bioavailability. To facilitate drug design, it is therefore essential to …
Influence of heterochirality on the structure, dynamics, biological properties of cyclic (PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis
I Bak-Sypien, T Pawlak, P Paluch, A Wroblewska… - Scientific Reports, 2024 - nature.com
Abstract Cyclic tetrapeptides c (Pro-Phe-Pro-Phe) obtained by the mechanosynthetic
method using a ball mill were isolated in a pure stereochemical form as a homochiral system …
method using a ball mill were isolated in a pure stereochemical form as a homochiral system …
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R)
L Mach, A Omran, J Bouma, S Radetzki, DA Sykes… - 2024 - chemrxiv.org
The cannabinoid receptor type 1 (CB1R) is one of the central elements of the
endocannabinoid system regulating a variety of signaling cascades. Extensive efforts on …
endocannabinoid system regulating a variety of signaling cascades. Extensive efforts on …
Influence of heterochirality on the structure, dynamics, biological properties of cyclic (PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis
M Potrzebowski, S Kazmierski, E Wielgus, P Paluch… - 2024 - researchsquare.com
Abstract Cyclic tetrapeptides c (Pro-Phe-Pro-Phe) obtained by the mechanosynthetic
method using a ball mill were isolated in a pure stereochemical form as a homochiral system …
method using a ball mill were isolated in a pure stereochemical form as a homochiral system …