Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth
factor family, regulates cell proliferation and signal transduction; moreover, EGFR is related …

Lung cancer is the leading cause of cancer-related mortality worldwide. The discovery of
tyrosine kinase inhibitors effectively targeting EGFR mutations in lung cancer patients in …

Abstract A Kinase Interacting Protein 1 (AKIP1) is found to be overexpressed in a variety of
human cancers and associated with patients' worse prognosis. Several studies have …

Hsp90s are ATP-dependent chaperones that collaborate with co-chaperones and Hsp70s to
remodel client proteins. Grp94 is the ER Hsp90 homolog essential for folding multiple …

Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important
strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the …

Lung cancer is one of the most prevalent tumors with rapid progression and poor prognosis,
which badly affects human physical and mental health. Although traditional anti-cancer …

Due to cell mutation and self-adaptation, the application of clinical drugs with early
epidermal growth factor receptor (EGFR)-targeted inhibitors is severely limited. To overcome …

Tumor metastasis is the major cause of breast cancer morbidity and mortality. It has been
reported that the F-box protein FBXO3 functions as an E3 ubiquitin ligase in regulating …

Uveal melanoma (UM) is the most common primary cancer of the eye in adults. A new
systemic therapy is needed to reduce the high metastasis and mortality rate. As β-blockers …

As a medicine-food homology (MFH) plant, golden-flowered tea (Camellia nitidissima Chi,
CNC) has many different pharmacologic activities and is known as “the queen of the tea …