MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a
majority of biological processes via regulating target gene expression. The post …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

À medida que a quantidade de informações em biologia aumenta exponencialmente, é
cada vez mais importante que os livros tenham a capacidade de transformar grandes …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Nuclear pore complexes (NPCs) restrict the nucleocytoplasmic flux of most macromolecules,
but permit facilitated passage of nuclear transport receptors and their cargo complexes. We …

Active transport between the nucleus and cytoplasm involves primarily three classes of
macromolecules: substrates, adaptors, and receptors. Some transport substrates bind …

Publisher Summary This chapter outlines the nucleocytoplasmic transport. The cell nucleus
is the most prominent cellular organelle and the defining feature of the eukaryotic branch of …

Pre-mRNAs undergo splicing to remove introns, and the spliced mRNA is exported to the
cytoplasm for translation. Here we investigated the mechanism for recruitment of the …