Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …

JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …

The advances in epigenetics for cancer radiotherapy

Y Wang, Y Han, Y Jin, Q He, Z Wang - International Journal of Molecular …, 2022 - mdpi.com
Cancer is an important factor threatening human life and health; in recent years, its morbidity
and mortality remain high and demosntrate an upward trend. It is of great significance to …

Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements

C Baumann, X Zhang, R De La Fuente - Journal of Cell Biology, 2020 - rupress.org
The polycomb group protein CBX2 is an important epigenetic reader involved in cell
proliferation and differentiation. While CBX2 overexpression occurs in a wide range of …

Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation

Y Chen, M Jiang, L Tian - BMC Medical Genomics, 2020 - Springer
Background Pancreatic cancer is one of the most malignant tumors. However, radiotherapy
can lead to tumor recurrence, which is caused by the residual surviving cells repopulation …

Spontaneous and ART-induced large offspring syndrome: similarities and differences in DNA methylome

Y Li, J Sena Lopes, P Coy-Fuster, RM Rivera - Epigenetics, 2022 - Taylor & Francis
Large/abnormal offspring syndrome (LOS/AOS) is a congenital overgrowth syndrome
reported in ruminants produced by assisted reproduction (ART-LOS) which exhibit global …

The RUNX/CBFβ complex in breast cancer: a conundrum of context

AS Khan, KJ Campbell, ER Cameron, K Blyth - Cells, 2023 - mdpi.com
Dissecting and identifying the major actors and pathways in the genesis, progression and
aggressive advancement of breast cancer is challenging, in part because neoplasms arising …

SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes

IY Kuo, YL Huang, CY Lin, CH Lin, WL Chang… - Journal of Biomedical …, 2019 - Springer
Background Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor
and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed …

Automatic Detection of the Circulating Cell-Free Methylated DNA Pattern of GCM2, ITPRIPL1 and CCDC181 for Detection of Early Breast Cancer and Surgical …

SC Wang, LM Liao, M Ansar, SY Lin, WW Hsu, CM Su… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is a multifactorial disease that arises from the cumulative
accumulation of acquired genetic as well as epigenetic alterations. Epigenetic alteration …

Persistent epigenetic changes in adult daughters of older mothers

AM Moore, Z Xu, RT Kolli, AJ White, DP Sandler… - Epigenetics, 2019 - Taylor & Francis
Women of advanced maternal age account for an increasing proportion of live births in many
developed countries across the globe. Offspring of older mothers are at an increased risk for …

Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016–2023

Y Yamada, T Imaoka, T Iwasaki… - Journal of Radiation …, 2024 - academic.oup.com
Abstract The Planning and Acting Network for Low Dose Radiation Research in Japan
(PLANET) was established in 2017 in response to the need for an all-Japan network of …