[HTML][HTML] Functionalized liposomes for targeted breast cancer drug delivery

J Nel, K Elkhoury, É Velot, A Bianchi, S Acherar… - Bioactive materials, 2023 - Elsevier
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

Ongoing clinical trials of nonviral siRNA therapeutics

EA Narasipura, R VanKeulen-Miller, Y Ma… - Bioconjugate …, 2023 - ACS Publications
Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

[HTML][HTML] Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1 …

B Han, H Zhang, R Tian, H Liu, Z Wang, Z Wang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Angiogenesis is a fundamental process of tumorigenesis, growth, invasion and
metastatic spread. Extracellular vesicles, especially exosomes, released by primary tumors …

Immunotherapy for colorectal cancer: mechanisms and predictive biomarkers

L Carlsen, KE Huntington, WS El-Deiry - Cancers, 2022 - mdpi.com
Simple Summary Late-stage colorectal cancer treatment often involves chemotherapy and
radiation that can cause dose-limiting toxicity, and therefore there is great interest in …

How EBV infects: the tropism and underlying molecular mechanism for viral infection

GL Bu, C Xie, YF Kang, MS Zeng, C Sun - Viruses, 2022 - mdpi.com
The Epstein–Barr virus (EBV) is associated with a variety of human malignancies, including
Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma and gastric cancers …

Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer

M Primeaux, X Liu, S Gowrikumar, I Fatima, KW Fisher… - Cancer Letters, 2023 - Elsevier
Therapy resistance is the primary problem in treating late-stage colorectal cancer (CRC).
Claudins are frequently dysregulated in cancer, and several are being investigated as novel …

Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy

YJ Yoo, CH Lee, SH Park, YT Lim - Journal of Controlled Release, 2022 - Elsevier
Although cancer immunotherapy has emerged as a novel cancer treatment modality, it still
suffers from low therapeutic efficacy in clinics due to the presence of a low number of …

[HTML][HTML] Crosstalk between skeletal and neural tissues is critical for skeletal health

N Abeynayake, A Arthur, S Gronthos - Bone, 2021 - Elsevier
Emerging evidence in the literature describes a physical and functional association between
the neural and skeletal systems that forms a neuro-osteogenic network. This communication …

[HTML][HTML] Recent advances in targeted gene silencing and cancer therapy by nanoparticle-based delivery systems

H Liu, X Zhu, Y Wei, C Song, Y Wang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Nanomedicine has emerged as a promising platform for disease treatment and much
progress has been achieved in the clinical translation for cancer treatment. Several types of …

EphA2: A promising therapeutic target in breast cancer

P Zhao, D Jiang, Y Huang, C Chen - Journal of Genetics and Genomics, 2021 - Elsevier
Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human
breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates …