G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Achieving the full potential of therapeutic proteins to access and target intracellular receptors
will have enormous benefits in advancing human health and fighting disease. Existing …

GRP/GRPR enhances alcohol-associated liver injury through th... : Hepatology GRP/GRPR
enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome …

Serotonin1A receptors are important neurotransmitter receptors in the G protein-coupled
receptor (GPCR) family and modulate a variety of neurological, behavioral, and cognitive …

Rabies virus (RABV) is a single-stranded negative-sense RNA virus belonging to the
Rhabdoviridae family and Lyssavirus genus, which is highly neurotropic and can infect …

Photoactivatable ligands remain valuable tools to study the spatiotemporal aspects of
cellular signaling. However, the synthesis, handling, and biological validation of such …

Background: Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) has been linked to the
pathogenesis of Alzheimer's disease (AD). Our recent study found significantly lower …

Numerous studies highlight the therapeutic potential of G protein-coupled receptor (GPCR)
heterodimers, emphasizing their significance in various pathological contexts. Despite …

Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled
acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a …

Unstructured regions in functional proteins have gained attention in recent years due to
advancements in informatics tools and biophysical methods. G protein-coupled receptors …