(1) Background: To develop evidence-based algorithms for targeted antibiotic therapy of
infection-related ventilator-associated complications (IVACs) caused by non-fermenting …

Background Therapeutic drug monitoring (TDM) may represent an invaluable tool for
optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers …

Introduction Neonatal infections caused by Gram-positive bacteria are commonly treated
with vancomycin. However, there is a lack of agreement on the optimal vancomycin dosing …

Background Linezolid is a broad-spectrum antimicrobial with limited use due to toxicity. This
study aimed to evaluate linezolid toxicity in a large multicentre cohort. Secondary objectives …

Background Current guidelines and literature support the use of therapeutic drug monitoring
(TDM) to optimize β-lactam treatment in adult ICU patients. Objectives To describe the …

Purpose To describe the implementation and operationalization of a β-lactam (BL)
therapeutic drug monitoring (TDM) program at a large academic center. Summary BLs are …

Introduction The growing spread of infections caused by multidrug-resistant pathogens
makes the need of tailoring antimicrobial therapies by means of a 'patient …

Background Recent studies demonstrated that failure of achieving pharmacodynamic
targets of commonly used antibiotics is common in critically ill patients. Therapeutic drug …

Objectives: The current practice of therapeutic drug monitoring (TDM) in Asia is poorly
documented. Our aim was to capture and describe TDM services delivered in hospitals …

Effective antimicrobial therapy remains paramount to successful treatment of patients with
critical illness, such as pneumonia and sepsis. Unfortunately, critically ill patients often …