Airway inflammation in COPD: progress to precision medicine

C Brightling, N Greening - European Respiratory Journal, 2019 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …

Links between inflammatory bowel disease and chronic obstructive pulmonary disease

AL Raftery, E Tsantikos, NL Harris… - Frontiers in …, 2020 - frontiersin.org
Inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD) are
chronic inflammatory diseases of the gastrointestinal and respiratory tracts, respectively …

Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease

SO Rodrigues, CMC Cunha, GMV Soares, PL Silva… - Pharmaceuticals, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …

Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait

B David, M Bafadhel, L Koenderman, A De Soyza - Thorax, 2021 - thorax.bmj.com
The heterogeneity of chronic obstructive pulmonary disease (COPD) creates many
diagnostic, prognostic, treatment and management challenges, as the pathogenesis of …

[PDF][PDF] Role of oxidative stress in the pathogenesis of COPD

F Nucera, S Mumby, KR Paudel, V Dharwal… - Minerva …, 2022 - opus.lib.uts.edu.au
Chronic inhalation of cigarette smoke is a prominent cause of chronic obstructive pulmonary
disease (COPD) and provides an important source of exogenous oxidants. In addition …

Th17/Treg imbalance in chronic obstructive pulmonary disease: clinical and experimental evidence

JD Lourenço, JT Ito, MA Martins, IFLC Tibério… - Frontiers in …, 2021 - frontiersin.org
The imbalance between pro-and anti-inflammatory immune responses mediated by Th17
and Treg cells is deeply involved in the development and progression of inflammation in …

Predicting the pulmonary effects of long-term e-cigarette use: are the clouds clearing?

LC Davis, E Sapey, DR Thickett… - European Respiratory …, 2022 - Eur Respiratory Soc
Commercially available since 2007, e-cigarettes are a popular electronic delivery device of
ever-growing complexity. Given their increasing use by ex-smokers, smokers and never …

Molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cell‐derived product “exo‐d‐MAPPS” in attenuation of chronic airway …

CR Harrell, D Miloradovic, R Sadikot… - Analytical Cellular …, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs), due to their potential for differentiation into alveolar
epithelial cells and their immunosuppressive characteristics, are considered a new …

Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)

P Upadhyay, CW Wu, A Pham, AA Zeki… - Journal of Toxicology …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

W Broekman, PPSJ Khedoe, K Schepers, H Roelofs… - Thorax, 2018 - thorax.bmj.com
COPD is characterised by tissue destruction and inflammation. Given the lack of curative
treatments and the progressive nature of the disease, new treatments for COPD are highly …