Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Fezolinetant (VEOZAH™) is an oral, small molecule, neurokinin 3 receptor (NK3R)
antagonist, which is being developed by Astellas Pharma Inc. for the treatment of moderate …

Abstract BACKGROUND The World Health Organization (WHO) system for the classification
of disorders of ovulation was produced 50 years ago and, by international consensus, has …

This study tested progesterone for perimenopausal hot flush±night sweat (vasomotor
symptom, VMS) treatment. It was a double-blind, randomized trial of 300 mg oral micronized …

Gonadotropin-releasing hormone (GnRH) is the final output of the central nervous system
that drives fertility. A characteristic of GnRH secretion is its pulsatility, which is driven by a …

Abstract Aims Neurokinin-B (NKB)-Neurokinin-3-receptor (NK3R) pathway is remarkably
sensitive to energy equilibrium; however, its role in metabolic regulation remains unexplored …

Preeclampsia is a blood pressure disorder associated with significant proteinuria.
Hypertensive women have increased levels of neurokinin B (NKB) and Cu (II) ions in blood …

The hypothalamus acts on the pituitary gland after signal integration, thus regulating various
physiological functions of the body. The pituitary gland includes the adenohypophysis and …

Background Ischemic heart disease (IHD) is a leading cause of mortality, particularly for
men. Few interventions have focused on protecting specifically men. Emerging evidence …

Introduction Menopausal vasomotor symptoms (VMS) are experienced by most women and
are often debilitating and can last for years. While hormone replacement therapy is effective …