Utrophin has been studied extensively in recent years in an effort to find a cure for
Duchenne muscular dystrophy. In this context, we previously showed that mice expressing …

Utrophin levels have recently been shown to be more abundant in slow vs. fast muscles, but
the nature of the molecular events underlying this difference remains to be fully elucidated …

Background Duchenne muscular dystrophy (DMD) is the most common, lethal disease of
childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other …

Abstract Development of gene therapy for the muscular dystrophies represents a daunting
challenge requiring significant advances in our knowledge of the defective genes, muscle …

MAPK signaling consists of an array of successively acting kinases. ERK1 and-2 (ERK1/2)
are major components of the greater MAPK cascade that transduce growth factor signaling …

Slower, more oxidative muscle fibers are more resistant to the dystrophic pathology in
Duchenne muscular dystrophy (DMD) patients as well as in the preclinical mdx mouse …

Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration
caused by lack of the cytoskeletal protein dystrophin. Dystrophin deficiency causes muscle …

During the evolution of humans, an inactivating deletion was introduced in the CMAH
(cytidine monophosphate–sialic acid hydroxylase) gene, which eliminated biosynthesis of …

Introduction: Duchenne muscular dystrophy (DMD) is the most common, severe childhood
form of muscular dystrophy. Treatment is limited to glucocorticoids that have the benefit of …

Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused
by lack of the cytoskeletal protein dystrophin. There is currently no cure for DMD although …