An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor

DM Black, RG Bakker-Arkema… - Archives of internal …, 1998 - jamanetwork.com
Background Statins (3-hydroxy-3-methylglutaryl–coenzyme A [HMG-CoA] reductase
inhibitors) have been used for a decade to lower low-density lipoprotein (LDL) cholesterol …

A brief review paper of the efficacy and safety of atorvastatin in early clinical trials

RG Bakker-Arkema, J Best, R Fayyad, TM Heinonen… - Atherosclerosis, 1997 - Elsevier
Preclinical and clinical data on atorvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A
(HMG-CoA) reductase inhibitor, indicate that it has superior activity in treating a variety of …

Atorvastatin Calcium: An Addition to HMG‐CoA Reductase Inhibitors

PH Chong, JD Seeger - Pharmacotherapy: The Journal of …, 1997 - Wiley Online Library
Atorvastatin calcium is an HMG‐coenzyme A (CoA) reductase inhibitor that was approved by
the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits …

Comparison of atorvastatin alone versus simvastatin ± cholestyramine in the management of severe primary hypercholesterolemia (The Six Cities Study)

LA Simons - Australian and New Zealand journal of medicine, 1998 - Wiley Online Library
Background: Atorvastatin is a new member of the class of drugs which inhibit the enzyme
Hydroxy‐Methylglutaryl Co‐A reductase, the rate limiting step in cholesterol biosynthesis …

[PDF][PDF] THE SAFETY AND EFFICACY OF ATROVASTATIN IN EARLY CLINICAL TRIALS

JB Salgar, SK Bais, BV Yeldi - 2023 - researchgate.net
ABSTRACT Atorvastatin, a novel 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase inhibitor, has demonstrated enhanced efficacy in managing various dyslipidemic …