刺五加多糖对氧化损伤大鼠的海马神经元OGG1 mRNA 表达的影响

刁波, 唐瑛, 杨李, 文晔 - 中国老年学杂志, 2009 - cqvip.com
目的研究刺五加多糖(ASPS) 对氧化损伤的海马神经元OGG1 mRNA 表达的影响, 为揭示ASPS
具有抵抗氧化损伤提供有力的实验依据. 方法运用海马神经细胞原代培养技术, 采用H2O2 …

用限制酶消化法检测脉孢菌中ung-1 基因的突变效应

国会艳, 刘秋月 - 牡丹江师范学院学报: 自然科学版, 2015 - cqvip.com
用限制酶消化法检测脉孢菌中ung-1 基因的突变效应. 以粗糙脉孢菌Ku70 为参照, 通过NaNO2
胁迫处理, 经DNA 提取, 限制酶消化, 检测ung-1 基因的缺失效应. 实验结果表明, ung-1 …

[PDF][PDF] An overview of the environmental genome project

DA Nickerson, MJ Rieder, DC Crawford… - Essays on the Future …, 2005 - p2infohouse.org
Understanding the causes of common diseases such as cancer, asthma, diabetes,
hypertension, and atherosclerosis, which have high population prevalence, is a significant …

Effect of oxidative stress on DNA repairing genes

B Cakmakoglu, ZB Cincin, M Aydin - Selected Topics in DNA …, 2011 - books.google.com
Oxidative DNA damage has been thought to contribute to the general decline in cellular
functions that are associated with a variety of diseases including Alzheimer disease …

hOGG1 基因在氯化镉恶性转化16HBE 细胞系过程中的表达

周志衡, 雷毅雄, 王彩霞, 王敏, 魏莲 - 中国热带医学, 2007 - cqvip.com
目的探讨OGG1 基因在氯化镉恶性转化16HBE 细胞过程中mRNA 的表达情况.
方法用半定量反转录-聚合酶链反应(FT-PCR) 技术检测16HBE 细胞, 氯化镉恶性转化16HBE …

8-oxoG 切除修复机制

郭晓强, 杨彩卿 - 医学分子生物学杂志, 2006 - cqvip.com
许多因素如活性氧类物质, 离子辐射等可引起碱基损伤, 如鸟嘌呤(G) 转变为8-氧鸟嘌呤(8-
oxoQ). 损伤的碱基可通过碱基切除修复通路得到纠正, 如DNA 糖基化酶负责8-oxoG 的修复 …

[HTML][HTML] Plausible Biochemical Mechanisms of Chemotherapy-induced Cognitive Impairment (“Chemobrain”), a Condition That Significantly Impairs the Quality of Life …

REN Xiaojia, D BORIERO, L CHAISWING… - … et biophysica acta …, 2019 - ncbi.nlm.nih.gov
Increasing numbers of cancer patients survive and live longer than five years after therapy,
but very often side effects of cancer treatment arise at same time. One of the side effects …

[图书][B] Synthesis of fluorinated analogs of oxidative DNA lesions and their use to probe features of recognition and repair by base excision repair glycosylases

S Cao - 2010 - search.proquest.com
Damage to DNA occurs through various sources, both exogenous and endogenous. Base
lesions resulting from the oxidation of guanine include 8-oxo-7, 8-dihydroguanine (OG) …

Characterisation of CSB ubiquitylation in response to UV-induced DNA damage

L Gaul - 2021 - discovery.ucl.ac.uk
A variety of DNA repair pathways operate in different cellular contexts to tackle a diversity of
DNA lesions and maintain genome stability. Nucleotide excision repair (NER) recognises …

hOGG1 基因多态性与肿瘤遗传易感性

殷明伟, 蒋燕, 刘彬 - 河南大学学报: 医学版, 2012 - cqvip.com
活性氧(reactive oxygen species, ROS) 攻击蛋白质, 脂类和DNA, 对细胞造成直接损伤,
其中对DNA 的损伤作用包括链的断裂和碱基修饰, 对鸟嘌呤的氧化作用产生8-羟基鸟嘌呤(8 …