DNA is continuously under stress from the insults inflicted by both endogenous and
exogenous agents. These agents include endogenous reactive oxygen species (ROS) …

Deamination and oxidation of pyrimidines are two major spontaneously damaging events in
DNA. The DNA glycosylase SMUG1 initiates repair of deaminated or oxidized bases by …

Pyrimidines are essential to the structure and function of nucleic acids in all organisms. The
chemical reactivity of the pyrimidines is therefore a fundamentally important aspect of …

Reactive oxygen species (ROS) oxidize the guanine base in the DNA to 8-oxoguanine (8-
oxoG). This lesion, if left unrepaired, causes the transversion of G: C pair to T: A following …

DNA damage can be caused through exposure to both exogenous and endogenous agents.
Through by-products of physiological cellular processes neurons are constantly exposed to …

La destruction radio-induite des complexes ADN-protéine peut avoir des conséquences
graves pour des systèmes impliqués dans des fonctions cellulaires importantes. Le premier …

More and more products containing nano-sized components are available. However,
exposure to nanomaterials is growing faster than the knowledge about possible adverse …

Oxidative deoxyribonucleic acid (DNA) damage is one of the major causes of neuronal
injury in ischemia. The endonuclease VIII‑like (NEIL) DNA glycosylases have a specific role …